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KMID : 1149220060140020067
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Korean Journal of Oriental Medical Prescription
2006 Volume.14 No. 2 p.67 ~ p.75
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Effects of ethanol extract of Nelumbo nucifera leaves on Anti-oxidation and Type I Procollagen Expression in CCD-986sk Cells
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Yang Woong-Mo
Kim Hyang-Mi
Chang Mun-Seog
Park Wan-Su
Kim Won-Nam
Kim San-Woong
Choi Dong-Gi
Lee Hak-Chul
Kim Yun-Kyung
Park Seong-Kyu
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Abstract
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The natural plants were screened for new cosmetic materials. Many parts of Nelumbo nucifera has been investigated for anti-wrinkling and anti-furrowing effects. The leaves. flowers and stamens of Nelumbo nucifera were extracted with ethanol or distilled water. The effects of cell viability and H2O2-induced cytotoxicity were studied on CCD-986sk human fibroblast cell line by MTT assay. We measured various effects related to skin such as the synthesis of MMP-1 and type I procollagen. The ethanol extract of Nelumbo nucifera leaves (ENL) at concentrations of 30 ㎍/㎖ showed maximum cell viability on CCD-986sk cells by 129.70%. and H2O2-induced cytotoxicity was blocked by ENL (5. 10. 20. 30. and 40 ㎍/㎖) concentration-dependently. The synthesis of MMP-1 and type I procollagen were positive in ENL. These results suggest that ENL has anti-oxidant and anti-furrowing effects.
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KEYWORD
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Nelumbo nucifera, CCD-986sk human fibroblast cell line, ethanol extract of Nelumbo nucifera leaves (ENL), MMP-1, type I procollagen
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